【Hacker News搬运】美国成年人镁消耗评分与代谢综合征

[hackernews]

Title: Magnesium Depletion Score and Metabolic Syndrome in US Adults

美国成年人镁消耗评分与代谢综合征

Text:

hn link

Url: https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgae075/7608307

文章标题为“Magnesium Depletion Score and Metabolic Syndrome in US Adults: Analysis of NHANES 2003 to 2018”，发表于《The Journal of Clinical Endocrinology & Metabolism》。文章通过分析2003至2018年美国国家健康和营养调查（NHANES）的数据，研究了镁耗竭分数（MDS）与代谢综合征（MetS）之间的关系。研究发现，较高的MDS与MetS的风险增加显著相关，每增加一个MDS单位，MetS的风险大约增加30%。即使在调整了可能的混杂因素后，这种正相关关系仍然显著。这项研究还发现，MDS与MetS之间的关系在不同的年龄、性别、种族、BMI、饮酒状况和吸烟状况的亚群中是一致的。总的来说，这项研究表明，由MDS反映的较高的镁缺乏状态是美国成年人MetS的一个稳健的独立风险因素，不受社会人口统计学和行为因素的影响。

Post by: voisin

Comments:

qwerty456127: A relevant anecdote: I unqualifiedly (being not a doctor) prescribed supplementing 400 mg of magnesium (in form of orotate or glycinate) daily to a number of volunteers (19-39 years old, both males and females) with signs of moderate to severe burnout, some of the them having mild forms of eating, alcohol abuse and sleeping disorders. Most of them reported quick yet sustaining life-changing improvements. One of them (having a history of severe psychological trauma) reported increase in nightmares though (nevertheless she lost a fair amount of excess weight and came to looking really great now). I concluded it is probably true that we all should supplement magnesium unless we know of a specific counter-indication in a specific case.

qwerty456127: 一个相关的轶事：我（不是医生）不情愿地给一些志愿者（19-39岁，男性和女性）开了每天补充400毫克镁（以乳清酸盐或甘氨酸盐的形式）的处方，这些志愿者有中度到重度倦怠的迹象，其中一些人有轻度的饮食、酗酒和睡眠障碍。他们中的大多数人报告说，他们的生活得到了迅速而持续的改善。其中一人（有严重心理创伤史）报告说噩梦增多（尽管如此，她还是减掉了相当多的超重，现在看起来真的很好）。我的结论是，除非我们知道在特定情况下有特定的反适应症，否则我们都应该补充镁，这可能是真的。

arcticbull: Remember not all magnesium supplements are absorbable by humans. Absorption of magnesium oxide and stearate is as low as 0-10% (common in supplements) while glycinate, orotate and L-threonate is closer to 100% and the latter seems particularly able to cross the blood brain barrier.

arcticbull: 请记住，并非所有的镁补充剂都能被人类吸收。氧化镁和硬脂酸盐的吸收率低至0-10%（在补充剂中常见），而甘氨酸、乳清酸和L-苏氨酸的吸收率接近100%，后者似乎特别能够穿过血脑屏障。

NalNezumi: Recently started to take magnesium supplements, after some Googling and finding an old HN post about experiences around it, going for glyciate rather than oxide (latter was the only one I could find at pharmacies).<p>In 1 week I've yet to experience any of the positive effects often listed (maybe slightly better sleep?) bar one surprise: I don't wake up for bathroom visit anymore.<p>Used to wake up once a night for toilet visit, but that disappeared. Anyone have had similar experience? My (old) father have been complaining about 2-4 toilet visit per night and was wondering if I should suggest magnesium supplement to him, or if this is just placebo.<p>I've read that too much magnesium hinder Zinc uptake, so I assume blindly suggesting it to others might have adverse effects depending on lifestyle

NalNezumi: 最近开始服用镁补充剂，在谷歌上搜索并找到一篇关于镁补充剂体验的旧HN帖子后，我选择了甘氨酸而不是氧化物（后者是我在药店唯一能找到的）<p> 在1周内；我还没有经历过经常列出的任何积极影响（也许睡眠稍微好一点？），除了一个惊喜：我不喜欢；我再也不会醒来去洗手间了<p> 以前每晚醒来上厕所一次，但现在已经不见了。有人有过类似的经历吗？我（老）父亲一直抱怨每晚上2-4次厕所，不知道我是否应该建议他补充镁，或者这只是安慰剂<p> I-；我读到过多的镁会阻碍锌的吸收，所以我认为盲目地向他人建议可能会对生活方式产生不利影响

modeless: Counter-anecdote: I took magnesium glycinate for a couple of months and saw no effect on sleep, blood pressure, or anything else.

modeless: 反轶事：我服用甘氨酸镁几个月，对睡眠、血压或其他任何东西都没有影响。

macawfish: If I remember right, magnesium supports production of a range of neurotransmitters, including those involved in dealing with stress. Specifically I believe it supports the metabolic processes involved in regulating the nervous system. I believe there have even been studies finding people with certain mental health conditions known to cause stress have chronically low magnesium levels.<p>But yeah it's an essential mineral and these days they don't feed the plants that grow food minerals as often as they used to. They feed them nitrogen but not necessarily minerals!

macawfish: 如果我没记错的话，镁支持一系列神经递质的产生，包括那些与应对压力有关的神经递质。具体来说，我相信它支持参与调节神经系统的代谢过程。我相信，甚至有研究发现，患有某些已知会导致压力的心理健康状况的人长期镁水平较低<p> 但是是的；是一种必需的矿物质，现在它们不；不要像过去那样经常给那些生长食物矿物质的植物喂食。它们给它们喂食氮，但不一定是矿物质！