【Hacker News搬运】减肥药物被发现可以缩小小鼠和人类细胞的心肌

[hackernews]

Title: Weight-loss drug found to shrink heart muscle in mice, human cells

减肥药物被发现可以缩小小鼠和人类细胞的心肌

Text:

hn link

Url: https://www.ualberta.ca/en/folio/2024/11/weight-loss-drug-found-to-shrink-heart-muscle.html

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Post by: Eumenes

Comments:

talkingtab: It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well.<p>What is the current comment receiving most of the comment?<p>"That's the sort of headlines that smells like bullshit to me"<p>That's the sort of comment that smells like bullshit to me. What kind of place is this?<p>Many times I find the posts on HN interesting, but increasingly these kind of comments make me wonder about Y Combinator. Is this really the best they can do?<p>And for us readers who are supposed to be so called hackers, is this the best we can do?

talkingtab: 我很关心像这次这样的关于HN的讨论是如何进行的。这是一个重要的话题。随着肥胖的流行，我们现在发现了一种吸引大量人的药物。这也是一个重要的话题<p> 目前收到最多评论的评论是什么<p> &quot；那；在我看来，这些头条新闻闻起来像是胡说八道<p> 那；在我看来，这种评论听起来像是胡说八道。这是什么地方<p> 很多时候，我觉得HN上的帖子很有趣，但越来越多的此类评论让我对Y Combinator感到好奇。这真的是他们能做的最好的吗<p> 对于我们这些被称为黑客的读者来说，这是我们能做的最好的事情吗？

cm2187: > <i>emerging research showing that up to 40 per cent of the weight lost by people using weight-loss drugs is actually muscle</i><p>That's the sort of headlines that smells like bullshit to me.<p>My understand of those drugs is that they don't actually make you lose weight, they just cut your appetite so you can follow a diet to lose weight without hunger hammering at the door. So to start with, if that's the case, all they are observing is the effect of a diet. Not sure the diet drug has much to do with it.<p>Then I went from 133kg to 88kg with these diet drugs. Even though I exercised every day, I am sure I also lost some muscle mass as well, just because I don't have to carry 45kg every time I make a move anymore. Seems logical and would probably be concerned if it was any other way.

cm2187: &gt<i> 新兴研究表明，使用减肥药的人减掉的体重中，高达40%实际上是肌肉</i><p>；对我来说，这些头条新闻闻起来像胡说八道。<p>我对这些药物的理解是，它们不会；实际上，它们不会让你减肥，只是会降低你的食欲，这样你就可以按照饮食减肥，而不会感到饥饿。因此，首先，如果；既然如此，他们所观察到的只是饮食的效果。不确定减肥药与此有多大关系。<p>然后我服用了这些减肥药，体重从133公斤增加到88公斤。尽管我每天都锻炼，但我确信我也失去了一些肌肉质量，仅仅是因为我没有锻炼；我再也不用每次搬家都背45公斤了。这似乎是合乎逻辑的，如果是其他方式，可能会感到担忧。

delichon: It also decreases gut motility, which helps with the intended effect of appetite suppression. Young healthy people tend to shrug at that. As an old person that takes it right off the menu even before I read about accelerated sarcopenea. Maybe it's the same effect on the peristaltic muscles.

delichon: 它还会降低肠道运动，这有助于抑制食欲的预期效果。健康的年轻人往往对此不屑一顾。作为一个老人，甚至在我读到加速石棺之前，就把它从菜单上拿下来了。也许吧；对蠕动肌也有同样的效果。

kbos87: There are a lot of people here citing loss of muscle mass as a side effect of GLP-1s, when the reality is that weight loss almost always comes with muscle loss.<p>For me, that hasn't even been the case. I'm down 40lbs on a relatively low dose of Semaglutide and my muscle mass has moderately increased over the last 6 months. The hysteria over this is totally unfounded.

kbos87: 这里有很多人认为肌肉质量的减少是GLP-1的副作用，而事实是体重减轻几乎总是伴随着肌肉减少<p> 对我来说，这并没有；事实并非如此。我；我服用了相对较低剂量的Semagutide，体重下降了40磅，在过去的6个月里，我的肌肉质量适度增加。对此的歇斯底里是完全没有根据的。

jyscao: When Ozempic started making the rounds in the news with glowing reviews, my instincts told me there likely was some long term negative effective that wasn't immediately apparent yet.<p>If something sounds good too good to be true, it usually is.

jyscao: 当Ozempic开始在新闻中广受好评时，我的直觉告诉我，可能有一些长期的负面影响；目前还不明显<p> 如果某事听起来好得令人难以置信，那么它通常是真的。